Research Articles 46 2. Yıl Cad. Nanoparticles are solid colloidal particles ranging in size from 10 to nm having high surface area-to-volume ratio which allows them for efficient interaction with biological systems. Nanoparticles offer many benefits in comparison to larger particles such as increased surface-to-volume ratio and increased magnetic properties. Nanomaterials hold the potential to revolutionize critical domains like Biomedicine, Drug Delivery, and Pharmaceutical Analysis. These particles can be functionalized with specific molecules to target diseased cells or tissues, enhancing the efficacy of drugs while minimizing side effects. For instance, gold nanoparticles conjugated with antibodies can be used for targeted cancer therapy, delivering therapeutic agents directly to tumor cells. Similarly, drugs encapsulated within nanoparticles can be protected from premature degradation and released in a controlled manner at the target site improving their drug solubility, and enhance cellular uptake, leading to better therapeutic effect in treatment strategies. Polymeric nanoparticles, liposomes, and micelles are some examples of commonly used nanocarriers for drug delivery. Nanomaterials are finding increasing applications in pharmaceutical analysis and can be employed as highly sensitive detection probes Escort Infrared Door Key drugs, metabolites, and biomarkers. Additionally, nanomaterials can be used for the separation and purification of biomolecules, Escort Infrared Door Key accurate and efficient analysis. As research continues to overcome current challenges, nanomaterials unique properties hold immense promise for revolutionizing healthcare and improving patient outcomes. The eye, which is essential for vision, is susceptible to diseases such as diabetic retinopathy, age-related macular degeneration, glaucoma, and dry eye syndrome. These conditions can significantly impair quality of life and lead to blindness. Traditional treatments for eye diseases, especially eye drops, have low bioavailability and short retention times on the ocular surface. To overcome these problems, new drug delivery systems such as hydrogels, contact lenses, microneedles, and nanosystems have been developed to increase drug penetration and maintain therapeutic effects. Drug delivery to the eye can occur via systemic, topical, intravitreal, intracorneal, subconjunctival, and suprachoroidal routes, each with different advantages and limitations. Systemic administration often results in low ocular drug concentrations and systemic side effects. Topical eye Escort Infrared Door Key are easy to apply and localized, but face difficulties in absorption and retention. Intravitreal and suprachoroidal injections provide targeted delivery to the posterior segment but are invasive and carry infection risks. Subconjunctival and intracorneal routes offer less invasive alternatives with improved targeting capabilities. Nanosystems and controlled-release technologies hold promise for overcoming current barriers and aim to increase drug bioavailability, extend release times, and improve patient compliance. Overall, advancing drug delivery methods is important for effective treatment of both anterior and posterior segment eye diseases. Thiazole derivatives have attracted much attention in medicinal chemistry due to their diverse pharmacological activities. This study provides an overview of the latest synthetic derivatives of thiazole and their therapeutic applications. Innovative methodologies have been adopted to enhance the structural diversity and optimize the pharmacological properties of thiazolebased compounds. These synthetic derivatives exhibit a broad spectrum of therapeutic activities, and understanding the essential features responsible for the observed pharmacological effects has been pivotal in structureactivity relationship studies. Drug development efforts have focused on modulating thiazole derivatives for improved bioavailability, selectivity, and reduced toxicity. This abstract highlights the potential of thiazole derivatives in targeting specific biological activity, paving the way for developing innovative therapeutic agents. Thiazole moiety as a heterocyclic compound was studied for its different pharmacological actions. The derivatives obtained from thiazole have diverse therapeutic actions along with antimicrobial activity, antitubercular activity, antidiabetic activity, anticonvulsant, anti-inflammatory actions, and antitumor activities. The mechanism of actions of all these activities is also studied by the researcher to provide scientific evidence and validation of their actions. Utilization of synthetic chemistry for exploration of various pharmacological potential of thiazole derivatives will lead the future pharmacologists to a newer dimension for new drug discovery and also these derivatives can be further optimized for the development of alternative options for the treatment of various diseases. The versatility of thiazole scaffolds presents promising opportunities for discovering new drugs with enhanced efficacy and improved pharmacokinetic profiles. As researchers continue to delve into the synthesis and pharmacological evaluation of thiazole derivatives, their significance in modern drug design and therapy becomes increasingly evident. Key Words: Thiazole, heterocyclic, antitubercular, antimicrobial, anti-inflammatory. Drug discovery as an important scientific area that serves human health, requires continuous advancement for improved quality of life and survival rates. However, drug discovery is a long and expensive process. The studies aimed at dealing with these problems have enabled to combination of artificial intelligence AI with drug development stages. Firstly, AI methods deep learning and convolutional neural networks help predict the 3D structure of protein making it easier for the rational design of compounds to target a specific protein among other potential outcomes.
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Volume 45, Issue 3 – FABAD Journal of Pharmaceutical Sciences Ocular Drug Delivery Routes: Diseases Overview and Advanced. Anticancer Property of Orthosiphon stamineus Benth. This issue is published electronically on December CONTENTS. Research Articles. Key Words: Biomedicine, Nanoparticles, Carbon nanotubes, Drug Delivery. Volume 46, Issue 2 – FABAD Journal of Pharmaceutical SciencesThe cytotoxic activity results showed that K2 platinum compound displayed Key Words: exendin-4, diabetes, oral route, pulmonary route,transdermal route, nanocarriers. NLCs were prepared via hot homogenisation technique using beeswax, carnauba wax, glyceryl monostearate solid lipids , linseed oil liquid lipid and poloxamer surfactant and optimized using custom design via JMP. The genetic algorithm GA and multiple linear regression analysis MLRA were used as appropriate techniques for descriptor selection and correlation model generation. When the histopathology of the disease is examined, senile amyloid plaques, neurofibrillary tangle formation, synapse-neuron loss, and marked atrophy in the brain are detected. Also, exendin-4 increases cell proliferation and inhibits apoptotic pathways in β-cells.
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Research Articles. Key Words: Biomedicine, Nanoparticles, Carbon nanotubes, Drug Delivery. Ocular Drug Delivery Routes: Diseases Overview and Advanced. The aircraft platform will be equipped with two turboprop engines and critical payloads such as EO/IR camera, AESA radar, Beyond Line of Sight (satellite). She alleged that she had been raped by two men on 31 July and 1 August , when she was 14 years and 10 months old. The ensuing investigation came to the. This issue is published electronically on December CONTENTS. Anticancer Property of Orthosiphon stamineus Benth.It is also a disease of inadequate control of glucose levels in the blood plasma. Cisplatin and carboplatin were used as reference drugs. To explore the stability profile of selpercatinib, it was subjected to forced degradation experiments including acidic, basic, oxidative, photolytic, and thermal stress. Nanosystems and controlled-release technologies hold promise for overcoming current barriers and aim to increase drug bioavailability, extend release times, and improve patient compliance. Additionally, high-performance liquid chromatographic HPLC method was developed for precise quantifying genotoxic impurities of selpercatinib. Furthermore, IFS-cubosomes were found to be more stable at refrigeration temperature than at room temperature. The loading capacity and encapsulation efficiency of the formulation are 4. Floating drug delivery systems FDDS are oral dosage forms that are able to float on the contents of the stomach and remain in the stomach for a long time. Wound dressings made of biodegradable polymers do not require a second procedure for removal. Diagnosis and treatment of acanthosis nigricans. This review presents an overview of radionuclide therapy used in bone metastases. Aging is considered an independent risk factor that impairs vascular function in humans and rodents. Thiazole derivatives have attracted much attention in medicinal chemistry due to their diverse pharmacological activities. Aerobic exercise improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. However; in topical applications, antifungal agents have difficulties sending to the target area. Gall extracts collected from different localities in Turkey and prepared with solvents of different polarity were investigated for both antioxidant and cytotoxic activity. The Fluconazole-loaded elastic liposome gel was prepared successfully and was found to be a good choice over conventional gel formulation for the treatment of keratomycosis. Key Words: Floating drug delivery systems, Gastro retentive, Effervescent, Non-effervescent, Novel floating drug delivery systems. This study investigates the digital data security awareness of pharmacy students and the effects of some variables on it. Since their easy formulation, thermodynamically stable properties, and facilitating the delivery of both lipophilic and hydrophilic active ingredients, loading resveratrol to microemulsions MEs will be a suitable delivery system to overcome the drawback of stability problems and skin bioavailability of resveratrol. Continuous process verification may be applicable to both a traditional and enhanced approach to pharmaceutical development. In addition, the effects of the extracts on the pancreatic cholesterol esterase enzyme were also investigated. However, studies and discussions continue in this area. Therefore, we aimed to examine the expression pattern of NLRP3 in peripheral blood mononuclear cells isolated from patients with RA using immunocytochemical approaches in this study. In this study, we investigated the effects of H2S and reactive oxygen species ROS on wound healing in fibroblasts under high glucose conditions. Key Words: Lavender oil, geranium oil, tea tree oil, nanoemulsion, ultrasonication. These experiments revealed the degradation of selpercatinib under basic, acidic, and photolytic conditions, resulting in the formation of five distinct DPs. Key Words: Fungal corneal ulcers, Fluconazole, elastic liposomal gel, antifungal activity. Liposomes, formed by lipid layers and an aqueous core, are micro- or nanometer-sized vesicular systems. Key Words: Caregiver, anxiety, depression, hemodialysis, objective burden, subjective burden. Increments in digital healthcare and digitally stored information raise concerns about data security. Caffeine is one of the naturally occurring xanthines in coffee beans, caffeine is the most commonly used psychoactive substance worldwide.
